C. elegans models of mitochondrial deficiency in the nervous system

Daniele Bano (DZNE), Siegfried Hekimi (CIHR), Mario de Bono (MRC)

Mitochondria are the intracellular organelles responsible for energy production. It is believed that broad decline in energy metabolism is strongly associated with the age-dependent loss of neuronal structures. Thus, the accumulation of mitochondrial defects during ageing likely promotes neurodegeneration. The proposal aims to study the molecular pathways and events that link mitochondrial defects and neurodegenerative diseases using the nematode C. elegans as a model system.  The use of genetic approaches will help to better understand the neurodegenerative process and might provide new therapeutic targets.

Welcome to our website, here you can inform yourself basically cookie-free.

We would be pleased if you would allow a cookie to be set for analysis purposes in order to optimise our provided information. All data are pseudonymous and are only used by the DZNE. We deliberately avoid third-party cookies. You can deselect this setting at any time here.

Your browser allows the setting of cookies: